Transdermal drug delivery via a hollow microneedle considering the skin's mechanical properties: Analytical and numerical study

Articles in Press

Document Type : Research Article

Authors

• Ebrahim Azhdari
• Aram Emami

Department of Mathematics and Computer Science, Faculty of Basic Sciences, Salman Farsi University of Kazerun, Kazerun, Iran.

10.22067/ijnao.2025.94641.1689

Abstract

Hollow microneedles have a significant impact on transdermal drug delivery by overcoming the stratum corneum layer of the skin and delivering drugs directly to living skin tissues. In this paper, using a mathematical model, the diffusion of nanocarriers, free drugs, and bound drugs in the microneedle channel, different skin's layers, and bloodstream are described. The mechanical properties of the skin, which affect drug delivery due to the elasticity and elastin present in the dermis of the skin, are considered. The qualitative behavior of the model is studied using energy estimation. The well-posedness of the fully coupled system is examined. Numerical simulation is used to study the model's numerical behavior and sensitivity analysis.

Keywords

• Mathematical model
• Numerical simulation
• Viscoelastic properties
• Energy estimate
• Hollow microneedles

Main Subjects

• Modeling and Simulation

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